into the seedpod of the poppy to release the thick, milky opium
        
        
          sap. Once exposed to the air, the sap turns into a brownish-
        
        
          black, gumlike substance. Natural opiates include morphine,
        
        
          heroin, and codeine.
        
        
          •
        
        
          
            
              Prescription painkillers
            
          
        
        
          are classified as opioids, and many
        
        
          people use them for severe pain. Opioids are synthetic forms
        
        
          of opiates, manufactured in legitimate laboratories for medical
        
        
          use and sometimes in illegal laboratories for recreational use.
        
        
          Opioids differ from opiates in their chemical structure, although
        
        
          they have similar effects on the human brain and body as
        
        
          do natural opiates. Like opiates, opioids can be extremely
        
        
          addictive. So they are often abused and cause a large number
        
        
          of nonlethal overdoses as well as overdose deaths. Opioids
        
        
          THE COST OF ADDICTION
        
        
          The addiction and overdose crisis in the United States takes a terrible toll in
        
        
          human suffering. It also has a gigantic monetary cost. A Beth Israel Deaconess
        
        
          Medical Center and VA Boston Healthcare System study reported in 2016 that
        
        
          the cost of hospitalizations in the United States for opioid abuse and dependence
        
        
          nearly quadrupled to $15 billion between 2002 and 2012. Of that, $700 million
        
        
          paid for hospitalizations related to opioid-associated infections. These infections
        
        
          of the bone, heart, and brain come from sharing dirty needles. The average cost
        
        
          per hospitalization for the treatment of opioid abuse was $28,000. Treatment for
        
        
          an infection associated with opioid abuse was more than $107,000.
        
        
          Dr. Shoshana Herzig, coauthor of the study, said, “The . . . consequences
        
        
          of opioid abuse and dependence, including serious infection, are
        
        
          severe—for individual patients and their loved ones, caregivers, hospital
        
        
          systems, and the federal government [the most common payer for opioid-
        
        
          associated hospitalizations].”
        
        
          10
        
        
          Addiction and Overdose